Colleton River is just 1.5 miles from the bridge to Hilton Head Island, making for the easiest of accesses. Simply turn onto Highway 278 and cross the bridge to Hilton Head. Continue over the bridge and look for signs for the Cross Island Expressway. If you are going to the south end of the island (Coligny, Forest Beach, Sea Pines, Shipyard) stay to your left and use the expressway (Toll $1.25) to save time. Otherwise, keep right and stay on Highway 278 Business.
Once you have arrived, be sure to stop in at the Hilton Head Welcome Center for more visitor information. Located on the right side of Highway 278 at 100 William Hilton Parkway, it's approximately one mile from the foot of the bridge as you come onto the Island. The Welcome Center is open 7 days a week, 9:00am-5:30pm (closed Thanksgiving, Christmas, and New Year's Day).
Flights to Hilton Head are also plentiful, with two airports servicing the region: Hilton Head Airport, located approximately 5 miles (8 km) from all Island resorts, and Savannah/Hilton Head International Airport, located approximately 45 miles (72 km) south of the Island.